Huw D Lewis Selected Research

Gamma Secretase Inhibitors and Modulators

2/2007	Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
7/2006	3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
11/2003	High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.
6/2003	Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
6/2003	Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.
1/2003	A new series of potent benzodiazepine gamma-secretase inhibitors.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Huw D Lewis Research Topics

Disease

13	Alzheimer Disease (Alzheimer's Disease) 09/2009 - 07/2002
2	Colitis 05/2022 - 04/2009
2	Rheumatoid Arthritis 10/2021 - 01/2021
2	Inflammation (Inflammations) 01/2019 - 04/2009
2	Neoplasms (Cancer) 04/2015 - 02/2007
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2022
1	Arthritis (Polyarthritis) 10/2021
1	Arthralgia (Joint Pain) 01/2021
1	Atherosclerosis 01/2019
1	Breast Neoplasms (Breast Cancer) 04/2015
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 02/2007
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/2007
1	Amyloid Plaque 02/2007
1	Amyloidosis 10/2004

Drug/Important Bio-Agent (IBA)

7	Amyloid beta-PeptidesIBA 09/2009 - 06/2003
6	Gamma Secretase Inhibitors and ModulatorsIBA 02/2007 - 01/2003
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2002
5	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 09/2009 - 01/2006
3	Peptides (Polypeptides)IBA 09/2009 - 06/2003
3	BenzodiazepinesIBA 11/2003 - 01/2003
2	Histone Deacetylase InhibitorsIBA 05/2022 - 01/2019
2	EnzymesIBA 04/2015 - 02/2007
2	Amyloid (Amyloid Fibrils)IBA 09/2009 - 07/2002
1	SodiumIBA 05/2022
1	Dextrans (Dextran)FDA Link 05/2022
1	AutoantibodiesIBA 10/2021
1	AntibodiesIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	CytokinesIBA 01/2019
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2019
1	Arginine (L-Arginine)FDA Link 04/2015
1	Estrogen ReceptorsIBA 04/2015
1	CalciumIBA 04/2015
1	Histones (Histone)IBA 04/2015
1	Protein-Arginine DeiminasesIBA 04/2015
1	Sulfonic AcidsIBA 04/2009
1	Pharmaceutical PreparationsIBA 04/2009
1	Sulfasalazine (Azulfidine)FDA LinkGeneric 04/2009
1	Biological ProductsIBA 07/2006
1	SulfonesIBA 07/2006
1	CyclohexaneIBA 07/2006
1	Peptide Hydrolases (Proteases)FDA Link 01/2006
1	Flavin-Adenine Dinucleotide (FAD)IBA 10/2004
1	Aspartic Acid ProteasesIBA 07/2002
1	Cathepsin DIBA 07/2002

Therapy/Procedure

2	Therapeutics 04/2009 - 10/2006
1	Immunotherapy 10/2021
1	Lasers (Laser) 10/2004